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Field	Response
Participation considerations from adversely impacted groups (protected classes) in model design and testing:	None of the Above
Measures taken to mitigate against unwanted bias:	Age, Ethnicity and Sex

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Geneformer

Model Overview

Description:

Geneformer generates a dense representation of a sc-RNA cell by learning co-expression patterns within single cells. Geneformer is a tabular count model trained on sc-RNA from the Chan Zuckerberg Cell x Gene census. Geneformer computes a complete embedding for each cell over the top 1024 expressed genes. The embeddings are used as features for a variety of predictive tasks. This model is ready for both commercial and academic use.

References:

Geneformer, reference foundation model for single-cell RNA: Transfer learning enables predictions in network biology | Nature
scGPT, alternative foundation model for single-cell RNA: scGPT: toward building a foundation model for single-cell multi-omics using generative AI | Nature Methods
scBERT, alternative foundation model for single-cell RNA: scBERT as a large-scale pretrained deep language model for cell type annotation of single-cell RNA-seq data | Nature Machine Intelligence
scFoundation, alternative foundation model for single-cell RNA: Large Scale Foundation Model on Single-cell Transcriptomics | bioRxiv\nCell x Gene census, public repository for sc-RNA experiments: CZ CELLxGENE Discover - Cellular Visualization Tool (cziscience.com)

Model Architecture:

Architecture Type: Bidirectional Encoder Representations from Transformers (BERT)
\nNetwork Architecture: Geneformer

Input:

Input Type(s): Number (Row represents cell, containing gene names and single cell expression counts)
\nInput Format(s): Array AnnData
\nInput Parameters: 1D

Output:

Output Type(s): Vector (Dense Embedding Predictions)embeddings.
\nOutput Format: NumPy
\nOutput Parameters: 1D
\nOther Properties Related to Output: Numeric floating point vector (fp16, bf16, or fp32); geneformer-10M-240530 outputs 256 dimensional embeddings; geneformer-106M-240530 outputs 768 dimensional embeddings

Software Integration:

Runtime Engine(s):

BioNeMo, NeMo 1.2

Supported Hardware Microarchitecture Compatibility:

Ampere
Hopper
Volta

[Preferred/Supported] Operating System(s):

Linux

Model Version(s):

geneformer-10M
\n
- 10.3M parameter geneformer variant.
- 25429 ensemble ID based gene tokens
- 256 hidden dimensions with 4 heads, 6 layers and an 512 dimensional FFN
- relu activation
- 1e-12 EPS layernorm
- bf16 mixed precision training with 32 bit residual connections
- 2% hidden dropout, 10% attention dropout
\n
geneformer-100M\n
- 106M parameter geneformer variant.
- 25429 ensemble ID based gene tokens
- 768 hidden dimensions with 12 heads, 12 layers and an 3072 dimensional FFN
- relu activation
- 1e-12 EPS layernorm
- bf16 mixed precision training with 32 bit residual connections
- 2% hidden dropout, 10% attention dropout
\n

Training & Evaluation:

Training Dataset:

Single cell expression counts from CELLxGENE Census used for the direct download of data matching similar criteria to those described in the geneformer publication. limiting cell data to organism=”Homo sapiens”, with a non “na” suspension_type, is_primary_data=True, and disease=”normal” to limit to non-diseased tissues that are also the primary data source per cell to make sure that cells are only included once in the download. We tracked metadata including “assay”, “sex”, “development_stage”, “tissue_general”, “dataset_id” and “self_reported_ethnicity”. The metadata “assay”, “tissue_general”, and “dataset_id” were used to construct dataset splits into train, validation, and test sets.

The training set represented 99% of the downloaded cells. We partitioned the data by dataset_id into a train set (99%) and a hold-out set (1%), to make sure that the hold-out datasets were independently collected single cell experiments, which helps evaluate generalizability to new future datasets.

In this training split, we made sure that all “assay” and “tissue_general” labels were present in the training set so that our model would have maximal visibility into different tissues and assay biases.

The 1% hold-out evaluation set was split further into a validation and test set. This final split was mostly done randomly by cell; however, we set aside a full dataset into the test split so that we could evaluate performance after training on a completely unseen dataset, including when monitoring the validation loss during training.

Link: Datasets downloaded from CZ CELLxGENE Discover - Cellular Visualization Tool (cziscience.com)
\n** Data Collection Method by dataset

[Human]

Labeling Method by dataset

Hybrid: Automated, Human

Properties (Quantity, Dataset Descriptions, Sensor(s)):
\n23.64 million non-diseased and human-derived single cells were chosen from the CZI CELLxGENE census, which is characterized as follows:

Assay Bias:\n
- The vast majority of the dataset is one of the 10x genomics assays, Approximately 20M of 26M cells are genomic assays, 4M are sci-RNA-seq, while Remaining assays (microwell-seq, drop-seq, bd rhapsody, smart-seq, seq-well, and MARS-seq) represent small fractions of the full datasets.
\n
Sex:\n
- 12.5M are male-derived cells; 10M are female derived cells. The remaining cells are not annotated.
\n
Self-Reported Ethnicity:\n
- Approximately 12M cells are not annotated; 9M are annotated as “European.” .5M are annotated as “Han Chinese.” followed by “African American”.
\n
Age Bias:\n
- The dataset is heavily biased toward donors less than one year. The next highest group would be the segment that includes ages 21-30.
\n
Tissue Type Bias:\n
- 9M cells are “brain” derived. 4M are blood derived, followed by “lung”, “breast”, “heart” and “eye” at approximately 1M cells each.
\n

Dataset was derived from a limited number of public sources where methods and protocols may not represent sufficiently diverse sources to capture the full scope of gene expression.

Evaluation Dataset:

Adamson et al 2016 PERTURB-seq dataset, accessed by Harvard dataverse.\nLink: adamson.zip - Harvard Dataverse
\nData Collection Method by dataset

Human

Labeling Method by dataset

Automated - Molecular Barcoding

Properties (Quantity, Dataset Descriptions, Sensor(s)): There are ~20k single cells, half of which represent unperturbed control samples, and the other half which contain an additional datatable containing the CRISPR knock-out targets for each cell.

Link: CZ CELLxGENE Discover - Cellular Visualization Tool (cziscience.com)
\nData Collection Method by dataset

Human

Labeling Method by dataset

Hybrid: Automated, Human

Properties (Quantity, Dataset Descriptions, Sensor(s)):

240,000 single cells were chosen from the CZI cell x gene census such that they did not share a dataset_id with any cell in the training data described previously.

Inference:

Engine: BioNeMo, NeMo
\nTest Hardware:

Ampere
Hopper
Volta

Training diagnostics

geneformer-10M-240530

This checkpoint was trained for approximately 11 epochs through the CELLxGENE split. Training was performed on 8 servers with 8 A100 GPUs each for a total of 115430 steps of per-gpu micro batch size 32 and global batch size of 2048. Training took a total of 1 day, 20 hours and 19 minutes of wallclock time. As can be seen in the following image, training and validation curves both decreased fairly smoothly throughout the course of training. In fact validation (blue) and training (orange) loss were both still decreasing at the end of 11 epochs through the dataset. The model could likely be trained for more epochs without overfitting.

geneformer-106M-240530

This checkpoint was trained for approximately 11 epochs through the CELLxGENE split. Training was performed on 16 servers with 8 A100 GPUs each for a total of 115430 steps of per-gpu micro batch size 16 and global batch size of 2048. Training took a total of 3 days, 18 hours and 55 minutes of wallclock time. As can be seen in the following image, training and validation curves both decreased fairly smoothly throughout the course of training. In fact validation (blue) and training (orange) loss were both still decreasing at the end of 11 epochs through the dataset. The model could likely be trained for more epochs without overfitting.

Additionally, validation loss decreased both faster and continued to decrease at the same improved rate throughout training in the 106M parameter model (red) as compared to the 10M parameter model (blue). It would be interesting to test even larger models to see if we continue to observe improved performance in larger models.

Benchmarking

Accuracy Benchmarks

Masked language model (MLM) loss

The following describes the bert MLM token loss. Like in the original BERT paper, and the geneformer paper, 15% of all tokens are included in the loss. Of the included tokens, 80% are \"[MASK]\" token, 10% are a random gene token, and 10% are the correct output token. The token loss in the following table is the mean cross entropy loss of the 15% of tokens included in the loss mask averaged across cells. As a baseline geneformer was downloaded from the ctheodoris/Geneformer page on hugging face on 2024/05/13 and applied to the same masking/unmasking problem on this dataset. The held-out test datset from our training splits described previously was used, and it should be noted that some of these cells may have been involved in training the baseline geneformer. Since the baseline performed slightly worse than our new checkpoints, and our goal was an equivalent or better model checkpoint, this possibility was not explored further.

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

tr:nth-child(odd)]:bg-surface-sunken\">

Model Description	Token Loss (lower is better)
Baseline geneformer	3.35
geneformer-10M-240530	2.79
geneformer-106M-240530	2.50

Performance Benchmarks

The 106M parameter variant of Geneformer achieves over 50 TFLOPS per GPU during training. This is consistent whether trained with 1 or 8 A100s.

License

Geneformer is available through Apache 2.0 license.

Ethical Considerations:

NVIDIA believes Trustworthy AI is a shared responsibility and we have established policies and practices to enable development for a wide array of AI applications. When downloaded or used in accordance with our terms of service, developers should work with their internal team to ensure this model meets requirements for the relevant industry and use case and addresses unforeseen product misuse. For more detailed information on ethical considerations for this model, please see the Model Card++ Explainability, Bias, Safety & Security, and Privacy Subcards [Insert Link to Model Card++ here]. Please report security vulnerabilities or NVIDIA AI Concerns here.

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\n**Network Architecture:** [Geneformer](https://rdcu.be/ddrx0)
\n\n#### Input:\n\n**Input Type(s):** Number (Row represents cell, containing gene names and single cell expression counts)
\n**Input Format(s):** Array [AnnData](https://anndata.readthedocs.io/en/latest/)
\n**Input Parameters:** 1D
\n\n#### Output:\n\n**Output Type(s):** Vector (Dense Embedding Predictions)embeddings.
\n**Output Format:** NumPy
\n**Output Parameters:** 1D
\n**Other Properties Related to Output:** Numeric floating point vector (fp16, bf16, or fp32); geneformer-10M-240530 outputs 256 dimensional embeddings; geneformer-106M-240530 outputs 768 dimensional embeddings
\n\n#### Software Integration:\n\n**Runtime Engine(s):**\n* BioNeMo, NeMo 1.2
\n\n**Supported Hardware Microarchitecture Compatibility:**
\n* Ampere
\n* Hopper
\n* Volta
\n\n**[Preferred/Supported] Operating System(s):**
\n* Linux
\n\n#### Model Version(s):\n\n* geneformer-10M
\n * 10.3M parameter geneformer variant.\n * 25429 ensemble ID based gene tokens\n * 256 hidden dimensions with 4 heads, 6 layers and an 512 dimensional FFN\n * relu activation\n * 1e-12 EPS layernorm\n * bf16 mixed precision training with 32 bit residual connections\n * 2% hidden dropout, 10% attention dropout\n* geneformer-100M\n * 106M parameter geneformer variant.\n * 25429 ensemble ID based gene tokens\n * 768 hidden dimensions with 12 heads, 12 layers and an 3072 dimensional FFN\n * relu activation\n * 1e-12 EPS layernorm\n * bf16 mixed precision training with 32 bit residual connections\n * 2% hidden dropout, 10% attention dropout\n\n### Training & Evaluation:\n\n#### Training Dataset:\n\nSingle cell expression counts from CELLxGENE Census used for the direct download of data matching similar criteria to those described in the geneformer publication. limiting cell data to organism=”Homo sapiens”, with a non “na” suspension_type, is_primary_data=True, and disease=”normal” to limit to non-diseased tissues that are also the primary data source per cell to make sure that cells are only included once in the download. We tracked metadata including “assay”, “sex”, “development_stage”, “tissue_general”, “dataset_id” and “self_reported_ethnicity”. The metadata “assay”, “tissue_general”, and “dataset_id” were used to construct dataset splits into train, validation, and test sets.\n\nThe training set represented 99% of the downloaded cells. We partitioned the data by dataset_id into a train set (99%) and a hold-out set (1%), to make sure that the hold-out datasets were independently collected single cell experiments, which helps evaluate generalizability to new future datasets.\n\nIn this training split, we made sure that all “assay” and “tissue_general” labels were present in the training set so that our model would have maximal visibility into different tissues and assay biases.\n\nThe 1% hold-out evaluation set was split further into a validation and test set. This final split was mostly done randomly by cell; however, we set aside a full dataset into the test split so that we could evaluate performance after training on a completely unseen dataset, including when monitoring the validation loss during training.\n\n**Link:** Datasets downloaded from [CZ CELLxGENE Discover - Cellular Visualization Tool (cziscience.com)](https://cellxgene.cziscience.com/)
\n** Data Collection Method by dataset
\n* [Human]
\n\n**Labeling Method by dataset**
\n* Hybrid: Automated, Human
\n\n**Properties (Quantity, Dataset Descriptions, Sensor(s)):** \n23.64 million non-diseased and human-derived single cells were chosen from the CZI CELLxGENE census, which is characterized as follows:
\n* Assay Bias:\n * The vast majority of the dataset is one of the 10x genomics assays, Approximately 20M of 26M cells are genomic assays, 4M are sci-RNA-seq, while Remaining assays (microwell-seq, drop-seq, bd rhapsody, smart-seq, seq-well, and MARS-seq) represent small fractions of the full datasets.\n* Sex:\n * 12.5M are male-derived cells; 10M are female derived cells. The remaining cells are not annotated.\n* Self-Reported Ethnicity:\n * Approximately 12M cells are not annotated; 9M are annotated as “European.” .5M are annotated as “Han Chinese.” followed by “African American”.\n* Age Bias:\n * The dataset is heavily biased toward donors less than one year. The next highest group would be the segment that includes ages 21-30.\n* Tissue Type Bias:\n * 9M cells are “brain” derived. 4M are blood derived, followed by “lung”, “breast”, “heart” and “eye” at approximately 1M cells each.\n\nDataset was derived from a limited number of public sources where methods and protocols may not represent sufficiently diverse sources to capture the full scope of gene expression.\n\n### Evaluation Dataset:\n\nAdamson et al 2016 PERTURB-seq dataset, accessed by Harvard dataverse.\n**Link:** [adamson.zip - Harvard Dataverse](https://dataverse.harvard.edu/file.xhtml?fileId=6154417)
\n**Data Collection Method by dataset**
\n* Human
\n\n**Labeling Method by dataset**
\n* Automated - Molecular Barcoding
\n\n**Properties (Quantity, Dataset Descriptions, Sensor(s)):** There are ~20k single cells, half of which represent unperturbed control samples, and the other half which contain an additional datatable containing the CRISPR knock-out targets for each cell.\n\n**Link:** [CZ CELLxGENE Discover - Cellular Visualization Tool (cziscience.com)](https://cellxgene.cziscience.com/)
\n**Data Collection Method by dataset**
\n* Human
\n\n**Labeling Method by dataset**
\n* Hybrid: Automated, Human
\n\n**Properties (Quantity, Dataset Descriptions, Sensor(s)):**\n* 240,000 single cells were chosen from the CZI cell x gene census such that they did not share a `dataset_id` with any cell in the training data described previously.\n\n#### Inference:\n\n**Engine:** BioNeMo, NeMo
\n**Test Hardware:**
\n* Ampere
\n* Hopper
\n* Volta
\n\n### Training diagnostics\n\n#### geneformer-10M-240530\n\nThis checkpoint was trained for approximately 11 epochs through the CELLxGENE split. Training was performed on 8 servers with 8 A100 GPUs each for a total of 115430 steps of per-gpu micro batch size 32 and global batch size of 2048. Training took a total of 1 day, 20 hours and 19 minutes of wallclock time. As can be seen in the following image, training and validation curves both decreased fairly smoothly throughout the course of training. In fact validation (blue) and training (orange) loss were both still decreasing at the end of 11 epochs through the dataset. The model could likely be trained for more epochs without overfitting.\n\n#### geneformer-106M-240530\n\nThis checkpoint was trained for approximately 11 epochs through the CELLxGENE split. Training was performed on 16 servers with 8 A100 GPUs each for a total of 115430 steps of per-gpu micro batch size 16 and global batch size of 2048. Training took a total of 3 days, 18 hours and 55 minutes of wallclock time. As can be seen in the following image, training and validation curves both decreased fairly smoothly throughout the course of training. In fact validation (blue) and training (orange) loss were both still decreasing at the end of 11 epochs through the dataset. The model could likely be trained for more epochs without overfitting.\n\nAdditionally, validation loss decreased both faster and continued to decrease at the same improved rate throughout training in the 106M parameter model (red) as compared to the 10M parameter model (blue). It would be interesting to test even larger models to see if we continue to observe improved performance in larger models.\n\n### Benchmarking\n\n#### Accuracy Benchmarks\n\n##### Masked language model (MLM) loss\n\nThe following describes the bert MLM token loss. Like in the original BERT paper, and the geneformer paper, 15% of all tokens are included in the loss. Of the included tokens, 80% are `\"[MASK]\"` token, 10% are a random gene token, and 10% are the correct output token. The token loss in the following table is the mean cross entropy loss of the 15% of tokens included in the loss mask averaged across cells. As a baseline geneformer was downloaded from [the ctheodoris/Geneformer page on hugging face on 2024/05/13](https://huggingface.co/ctheodoris/Geneformer) and applied to the same masking/unmasking problem on this dataset. The held-out `test` datset from our training splits described previously was used, and it should be noted that some of these cells may have been involved in training the baseline geneformer. Since the baseline performed slightly worse than our new checkpoints, and our goal was an equivalent or better model checkpoint, this possibility was not explored further.\n\n| Model Description | Token Loss (lower is better) |\n|--------------------------------|------------|\n| Baseline geneformer | 3.35 |\n| geneformer-10M-240530 | 2.79 |\n| geneformer-106M-240530 | 2.50 |\n\n#### Performance Benchmarks\n\nThe 106M parameter variant of Geneformer achieves over 50 TFLOPS per GPU during training. This is consistent whether trained with 1 or 8 A100s.\n\n#### License\nGeneformer is available through Apache 2.0 license.\n\n#### Ethical Considerations:\n\nNVIDIA believes Trustworthy AI is a shared responsibility and we have established policies and practices to enable development for a wide array of AI applications. When downloaded or used in accordance with our terms of service, developers should work with their internal team to ensure this model meets requirements for the relevant industry and use case and addresses unforeseen product misuse. For more detailed information on ethical considerations for this model, please see the Model Card++ Explainability, Bias, Safety & Security, and Privacy Subcards [Insert Link to Model Card++ here]. Please report security vulnerabilities or NVIDIA AI Concerns [here](https://www.nvidia.com/en-us/support/submit-security-vulnerability/).","displayName","Geneformer 10M",["D",1737486110965],"publisher","NVIDIA","latestVersion","versions","collectionCounts","imageUrl","/api/image/nvidia/clara/models/geneformer_10m","rawImageUrl","https://assets.nvidiagrid.net/ngc/logos/Clara.png","canGuestDownload","latestVersionSizeInBytes",132366315,"licenseTerms","isMultinodeEnabled","isMultiArchitecture","bias","Field | Response\n:---------------------------------------------------------------------------------------------------|:--------------------------------------------------------------------------------------------------------------------------\nParticipation considerations from adversely impacted groups [(protected classes)](https://www.senate.ca.gov/content/protected-classes) in model design and testing: | None of the Above\nMeasures taken to mitigate against unwanted bias: | Age, Ethnicity and Sex","explainability","Field | Response\n:------------------------------------------------------------------------------------------------------|:-------------------------------------------------------------------------------------------------------------------\nIntended Application(s) & Domain(s): | Generates representations of cells from genes \nModel Type: | Gene Expression Representation\nIntended Users: | This model is intended for academic and industrial computational biologists who study and perform experiments with single cell RNA sequencing data.\nOutputs: | Gene Expression Embeddings\nDescribe how the model works: | Outputs a dense embedding based on masked genes and classification targets. \nTechnical Limitations: | The model does not take into account the magnitude of gene expression, only the rank. The model is technically limited to only observing 1000-2000 genes rather than the entire set of possible targets (~20,000).\nVerified to have met prescribed NVIDIA standards: | Yes\nPerformance Metrics: | * Reconstruction Error (Cross Entropy)
* Cell Type Classification
\nPotential Known Risks: | The model may not work on cell types and genes unrelated to neuronal gene expression; model accuracy should be further researched for potential differences in population based on age, sex, and ethnicity. \nLicensing: | [Apache 2.0](https://www.apache.org/licenses/LICENSE-2.0)","privacy","Field | Response\n:----------------------------------------------------------------------------------------------------------------------------------|:---------------------------------\nGeneratable or reverse engineerable personally-identifiable information (PII)? | None\nProtected classes used to create this model? | Not Applicable\nWas consent obtained for any PII used? | Not Applicable\nHow often is dataset reviewed? | Before Release\nIs a mechanism in place to honor data subject right of access or deletion of personal data? | Yes, Via Principal Investigator.\nIf PII collected for the development of the model, was it collected directly by NVIDIA? | Not Applicable\nIf PII collected for the development of the model by NVIDIA, do you maintain or have access to disclosures made to data subjects? | Not Applicable\nIf PII collected for the development of this AI model, was it minimized to only what was required? | Yes\nIs there provenance for all datasets used in training? | Yes\nDoes data labeling (annotation, metadata) comply with privacy laws? | Not Applicable\nIs data compliant with data subject requests for data correction or removal, if such a request was made? | Yes\nApplicable NVIDIA Privacy Policy | https://www.nvidia.com/en-us/about-nvidia/privacy-policy/","safetyAndSecurity","Field | Response\n:---------------------------------------------------|:------------------------------------------------------------------\nModel Application(s): | Drug target identification, cell biology discovery, and cell engineering\nDescribe the life-critical application (if present).| None\nUse Case Restrictions: | Abide by Apache 2.0\nDescribe access restrictions (if any): | The Principle of least privilege (PoLP) is applied limiting access for dataset generation and model development. 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We and our advertising partners will use this information to make our websites and the advertising displayed on it, more relevant to your interests.",5,[459,460,461,462,463,464,465,466,467,468,469,470,471,472,473,474,475,476,477,478,479,480,481,482,483,484,485,486,487,488,489,490,491,492,493],[331,332,333,334,335,336,337,338,339,340,341,342,343,344,345,346,347],{"_348":455,"_161":455,"_109":350,"_321":456},{"_348":450,"_161":450,"_109":350,"_321":451},{"_348":446,"_161":446,"_109":350,"_321":447},{"_348":441,"_161":441,"_109":350,"_321":442},{"_348":436,"_161":436,"_109":350,"_321":437},{"_348":424,"_161":424,"_109":350,"_321":425},{"_348":412,"_161":412,"_109":350,"_321":413},{"_348":407,"_161":407,"_109":350,"_321":408},{"_348":396,"_161":396,"_109":350,"_321":397},{"_348":391,"_161":391,"_109":350,"_321":392},{"_348":386,"_161":386,"_109":350,"_321":387},{"_348":381,"_161":381,"_109":350,"_321":382},{"_348":376,"_161":376,"_109":350,"_321":377},{"_348":371,"_161":371,"_109":350,"_321":372},{"_348":366,"_161":366,"_109":350,"_321":367},{"_348":359,"_161":359,"_109":350,"_321":360},{"_348":349,"_161":349,"_109":350,"_321":351},"hostName","amazon-adsystem.com","",[352,353],{"_141":358,"_355":349,"_356":20,"_109":357},{"_141":354,"_355":349,"_356":20,"_109":357},"ad-privacy","host","isSession","This domain is owned by online retailer Amazon and is used as part of its affiliate marketing programme.","ad-id","doubleclick.net",[361,362],{"_141":365,"_355":359,"_356":20,"_109":364},{"_141":363,"_355":359,"_356":20,"_109":364},"IDE","This domain is owned by Doubleclick (Google). 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These cookies enable us to provide enhanced website functionality and personalization as well as make the marketing messages we send to you more relevant to your interests. If you do not allow these cookies, then some or all of these services may not function properly.",[581,582,583,584,585,586,587,588,589,590,591,592,593,594,595,596,597,598,599,600,601],[546,547,548,549,550],{"_348":441,"_161":441,"_109":350,"_321":572},{"_348":407,"_161":407,"_109":350,"_321":567},{"_348":560,"_161":560,"_109":350,"_321":561},{"_348":556,"_161":556,"_109":350,"_321":557},{"_348":551,"_161":551,"_109":350,"_321":552},"nvcrm.my.site.com",[553],{"_141":554,"_355":551,"_356":20,"_109":555},"BrowserId","If you know anything about this cookie and its uses that are not specific to a particular site please add your contributions.","nvidia.partners",[558],{"_141":559,"_355":556,"_356":20,"_109":390},"edge","github.com",[562,563],{"_141":566,"_355":560,"_356":20,"_109":565},{"_141":564,"_355":560,"_356":20,"_109":565},"logged_in","This domain is owned by Github. 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